Meticulous Management of a Case of Severe Ovarian Hyperstimulation Syndrome Using Dopamine Agonist and GnRH Antagonist: a Case Report

Abstract

Ovarian hyperstimulation syndrome (OHSS) is characterised by increased capillary permeability and thus fluid shift from intravascular to extravascular compartment. Presence of abdominal distension causing discomfort to the patient, diameter of ovary more than 12 cm and ascites are the criteria to diagnose a case of severe OHSS. A, 28-year-old patient, P4L5 presented to our hospital, after ovulation induction and pick-up for oocyte donation, with abdominal distension and pain. She has history of severe OHSS, 4 months back as well. She was managed symptomatically, with close watch on her vitals, input-output, hematological and ultrasonological parameters. She was administered dopamine agonist in a dose of 1 mg/day and GnRH antagonist, injection cetrorelix 0.25 mg subcutaneously for 7 days. Paracentesis was also done twice for the patient under ultrasound guidance. Patient improved significantly over the course and was discharged in a stable condition.