The Effects of Noise Pollution on the Cell Senescence

Abstract

Noise pollution, primarily caused by human activities, refers to unwanted ambient noise that adversely affects quality of life and health. The World Health Organization (WHO) and the Environmental Protection Agency (EPA) suggest a safe noise exposure level of 70 dB. Noise pollution can lead to significant health issues. It is supposed that noise pollution accelerates cellular senescence, characterized by cell cycle arrest, metabolic changes, inducing inflammation. Although there is no direct evidence to show the relation of noise exposure and induction of cell senescence, the noise pollution often mediated some key proteins involve in cell senescence like p53 and AMPK. It also affects mitochondrial function, leading to increased reactive oxygen species (ROS), reduced telomerase activity and change in pro-inflammatory cytokines. Chronic noise exposure alters cellular signaling pathways and metabolic responses, highlighting the need for further understanding of its impact on health and aging. Overall, noise pollution poses significant risks to human health and cellular dynamics, necessitating attention to environmental noise levels.